Last edited by John Wiley & Sons
10.08.2021 | History

3 edition of Immunotoxicology strategies for pharmaceutical safety assessment found in the catalog.

Immunotoxicology strategies for pharmaceutical safety assessment


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      • Includes bibliographical references and index.

        StatementJohn Wiley & Sons
        PublishersJohn Wiley & Sons
        LC Classifications2008
        The Physical Object
        Paginationxvi, 60 p. :
        Number of Pages42
        ID Numbers
        ISBN 10nodata
        Introduction to immunotoxicology / Jack H. Dean Current regulatory expectations for immunotoxicity evaluation of pharmaceuticals / Kenneth L. Hastings Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley Need for specialized immunotoxicity tests / Kazuchi Nakamura Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj T-cell dependent antibody response tests / Joseph R. Picotti Natural killer cell assay and other innate immunity tests / Lisa Plitnick Cellular immune response in delayed hypersensitivity test / Karen Price Evaluation of drug effects on immune cell phenotypes / Laurie Iciek Functional cellular responses and cytokine profiles / Elizabeth R. Gore Application of flow cytometry in drug development / Padma Narayanan, Nianyu Li, and Peter J. Bugelski Animal models of host resistance / Gary R. Burleson and Florence G. Burleson Approaches to evaluation of autoimmunity / Danuta J. Herzyk Differentiation between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere Anti-drug antibody responses in preclinical studies and their implications / Barbara Mounho Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski ... [et al.] Systemic hypersensitivity / Raymond Pieters Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas Developmental immunotoxicity in non-human primates / Pauline L. Martin and Eberhard Buse Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski Animal models for preclinical comparative immunogenicity testing / Daniel Wierda T-cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes.

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Immunotoxicology strategies for pharmaceutical safety assessment by John Wiley & Sons Download PDF EPUB FB2

antigen-presenting cells dendritic cells, Langerhans cells, macrophagesT lymphocytes Th1, Th2, Treg, Th17 and B lymphocytes interacting with each other.

Steven Ryder, Ethan Weiner, in2009 Nonclinical Safety Assessment Nonclinical safety assessment provides the indispensable foundation for the initiation and conduct of human drug testing. Nonclinical Models to Assess Respiratory HypersensitivityPotential Curtis C. The need for policy changes and curricula changes in the relevant areas are highlighted. aids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing• 139 We recently also developed a high frequency RWG imager to measure the compound-induced cardiotoxicity Fig.

This chapter introduces various medicine use-related problems in Nepal and provides an overview on existing knowledge on these issues.

Immunotoxicology Strategies for Pharmaceutical Safety Assessment edited by Danuta J. Herzyk and Jeanine L. Bussiere

An extensive explanation of the function histophysiology and pathophysiology of the immune system emphasizes features that can aid the understanding and interpretation of the pathological changes caused by immunotoxic insults. Publisher Name Springer, Berlin, Heidelberg• helps readers understand the significance of the methods and approaches to immunotoxicology testing• includes chapter authors from across the pharma industry, bringing a real-world and applied perspective to immunotox testing Contents• Therefore, a weight-of-the-evidence approach, which takes into account a variety of factors and approaches for an overall assessment of allergenic potential, is conducted.

Safety evaluations are continued and intervals between doses may continue to be determined. The book opens with a detailed basic introduction to immunotoxicology.

Part II: Weight of Evidence Review: A New Strategy InImmunotoxicology. " New chapters discuss the role of immune mediators in liver, lung, and skin toxicity, in regulating chemical- metabolizing enzymes, and in the immunosuppression produced by ultraviolet light.

Safety Assessment

The treatment of cardiomyocytes with isradipine, a known toxic compound, for 1 min completely stopped their beating. Our library is the biggest of these that have literally hundreds of thousands of different products represented. The developed models can be used as tools for screening new drugs or drug impurities for their mutagenicity assessment for regulatory purpose.

Strengths and Limitations of Earthworm Immunotoxicity Tests Screening vs.